Anti-Estrogen Calcium D-Glucarate

Calcium D-Glucarate an effective estrogen regulator?

Calcium D-Glucarate estrogen regulator

Calcium D-Glucarate (calcium salt of D-glucaric acid) is produced naturally in small amounts by mammals, and can be found in variety of fruits and vegetables (oranges, apples, grapefruit, and cruciferous vegetables) [1]. Calcium D-glucarate is made by combining glucaric acid with calcium to make supplements that people use for medicine [2].

Calcium D-Glucarate as Estrogen Blocker

Oral supplementation of calcium D-glucarate has been shown to inhibit beta-glucuronidase via its precursor D-glucaro-1,4-lactone [3] (thus increasing glucuronidation process [8]). Elevated beta-glucuronidase activity is associated with an increased risk for various cancers (especially hormone-dependent such as breast, prostate, and colon cancer) [1,4,5]. Therefore, calcium D-glucarate is a promising natural solution for the prevention of certain types of cancer. Clinical applications of oral calcium D-glucarate also include regulation of estrogen metabolism [4,6].

Calcium D-glucarate’s inhibition of beta-glucuronidase activity allows the body to eject hormones such as estrogen before they can become reabsorbed. Supplementation of very large doses of calcium D-glucarate have been shown to decrease serum estrogen levels in rats by 23 percent. [6] However, doses used are so high (approx. 1,000mg/kg) they seem impractical for actual use.

Calcium D-Glucarate Side Effects and Risks

There is not enough information to know if calcium D-glucarate is safe or what the potential side effects might be [2]. Preliminary results of clinical trials in humans show no adverse effects [1]. There are no known drug interactions with calcium D-glucarate, but many drugs and hormones are metabolized in the liver via glucuronidation, thus, supplementing with calcium D-glucarate may increase ejection of these substances and reduce their effectiveness [1]. Testosterone is also a hormone that is glucuronidated, which means calcium D-glucarate may limit the bioavailability of testosterone [7].

(Other common names: Calcium-D Glucarate, Calcium-D-Glucarate, D-Glucarate (GA), D-glucaro-1,4-lactone (1,4 GL))


  1. Calcium-D-glucarate. Retrieved from Retrieved 7. May 2013
  2. Find a Vitamin or Supplement – “Calcium D – Glucarate” Retrieved from Retrieved 7. May 2013
  3. Dwivedi C, Heck WJ, Downie AA, et al. “Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits.” Biochem Med Metab Biol 1990;43:83-92.
  4. Walaszek, Z., et al. “Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention.” Cancer detection and prevention 21.2 (1997): 178.
  5. Hanausek, Margaret, Zbigniew Walaszek, and Thomas J. Slaga. “Detoxifying cancer causing agents to prevent cancer.” Integrative Cancer Therapies 2.2 (2003): 139-144.
  6. Walaszek, Zbigniew, et al. “Dietary glucarate as anti-promoter of 7, 12-dimethylbenz [a] anthracene-induced mammary tumorigenesis.” Carcinogenesis 7.9 (1986): 1463-1466.
  7. Pacifici, G. M., A. Gucci, and L. Giuliani. “Testosterone sulphation and glucuronidation in the human liver: interindividual variability.” European journal of drug metabolism and pharmacokinetics 22.3 (1997): 253-258.
  8. Retrieved 2. May 2014