Conezyme Q10 Health & Wellness

Coenzyme Q10 (CoQ10) – moderate effects on exercise

Heart health Coenzyme Q10

Coenzyme Q10 (abbreviated as CoQ10, CoQ, or Q10) is vitamin-like substance that is oil-soluable and is present in almost every cell, primarily in the mitochondria [1]. Q refers to the quinone head and 10 refers to the number of isoprene repeats in the tail (pic.1). CoQ10 helps convert food into energy and is a powerful antioxidant [1]. Numerous studies were conducted on this molecule in relation to various diseases including cardiovascular diseases and cancer.

Coenzyme Q10 and its role in exercise

In 2003, Rosenfeldt and others [2] systematically reviewed the effect of coenzyme Q10 in physical exercise. They identified eleven studies in which CoQ10 was tested for an effect on exercise capacity. Six of these studies showed moderate effects on exercise, while five showed no effect.

A more recent study [3] in trained and untrained population wanted to determine whether single dose or chronic (14-days) supplementation of CoQ10 will improve anaerobic or aerobic exercise performance by increasing plasma and muscle CoQ10 concentrations. After 2 weeks of CoQ10 supplementation researchers noted increased plasma CoQ10 concentrations which could explain the increased time to exhaustion.

Bonetti and assistants [4] attributed little improvement of tolerance to higher workloads to the antioxidant activity of Coenzyme Q10.

Even though there are some studies [2-4] that are reporting improvements in aerobic/anaerobic power, and recovery following CoQ10 supplementation, the potential ergogenic value of CoQ10 in healthy trained individuals remains unclear.

Other uses for Coenzyme Q10

Coenzyme Q10 chemical structure

Pic. 1 – Chemical structure of coenzyme Q10 (the quinone head and tail with ten isoprene repeats)

There is some evidence that CoQ10 may improved cardiac function in people with congestive heart failure (CHF) when combined with conventional medications [1]. Prof. C. Morisco and assistants [5] demonstrated (in the largest published placebo-controlled trial of CoQ10 in CHF) that the addition of coenzyme Q10 to conventional therapy significantly reduces hospitalization for worsening of heart failure in patients with chronic congestive heart failure. Another large scale study (422 patients with CHF) named Q-SYMBIO (focus on SYMptoms, BIOmarker status) reported to significantly reduced all-cause mortality after 2 years compared with placebo [6].

In a review study evaluating 12 clinical studies, researchers concluded that CoQ10 has the potential to lower blood pressure, without significant side effects [1].

Side effects, risks and precautions

Coenzyme Q10 appears to be generally safe with no major side effects, except occasional stomach upset [1,3].

References

  1. University of Maryland Medical Center. Retrieved from http://www.umm.edu/ at 11. May 2013
  2. Rosenfeldt, Franklin, et al. “Systematic review of effect of coenzyme Q _ {10} in physical exercise, hypertension and heart failure.” Biofactors 18.1 (2003): 91-100.
  3. Cooke, Matthew, et al. “Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals.” Journal of the International Society of Sports Nutrition 5.1 (2008): 1-14.
  4. Bonetti A, Solito F, et al. “Effect of ubidecarenone oral treatment on aerobic power in middle-aged trained subjects.” J Sports Med Phys Fitness. (2000): 51–57.
  5. Morisco, C., B. Trimarco, and M. Condorelli. “Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study.” The clinical investigator 71.8 (1993): S134-S136.
  6. Stocker, Roland, and Peter Macdonald. “The benefit of coenzyme Q10 supplements in the management of chronic heart failure: a long tale of promise in the continued absence of clear evidence.” The American journal of clinical nutrition 97.2 (2013): 233-234.

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