Creatine Increase Endurance Increase Strength Muscle Gain

Kre Alkalyn no better than creatine monohydrate

Kre Alkalyn (a.k.a. buffered creatine monohydrate) is yet another form of creatine which is marketed as a more efficacious and safer form of creatine than creatine monohydrate[1].

Kre Alkalyn is supposed to be “pH correct” form of creatine that remains more stable in the stomach, and is not degraded to creatinine. It is explained in the patent [2] that this is acquired by adding alkaline powder (e.g., soda ash) which adjusts the pH to a range between 7–14. In fact, study presented at the International Society of Sports Nutrition annual meeting in 2007 [3] reported that conversion of creatine to creatinine was 35% greater with Kre Alkalyn compared to creatine monohydrate.

Jagim, A. R., et al [4] decided to put these claims to the test. 36 resistance trained participants aged between 20 and 22 were assigned to supplement with either (20 g/day for 7 days, 5 g/day for 21 days) creatine monohydrate (Creapure), equal amount of Kre Alkalyn (KL1) or the manufacturer’s recommended dose of Kre Alkalyn (1.5 g/day )(KL2) for 28 days. They measured muscle biopsy, fasting blood samples, body weight, body composition, 1RM bench press and leg press.

The results of the study have shown that neither KL1 nor KL2 group promoted greater changes in muscle creatine content, body composition, strength, or anaerobic capacity compared to creatine monohydrate group. There was also no evidence that buffered creatine is a safer form of creatine.

Since no greater gains were noted, it was concluded that Kre Alkalyn is not a better form of creatine.

This study was supported by AlzChem AG, the company that makes creatine (Creapure).


  1. Kre-Alkalyn – The World’s Most Potent Creatine. Retrieved 11 Feb 2013
  2. Golini, Jeffrey M. “Oral creatine supplement and method for making same.” U.S. Patent No. 6,399,661. 4 Jun. 2002.
  3. Tallon MJ, Child R. Kre-alkalyn® supplementation has no beneficial effect on creatine-to-creatinine conversion rates. International Society of Sports Nutrition Annual Conference, Las Vegas, NV; 2007.
  4. Jagim, A. R., et al. “Kre-Alkalyn® supplementation does not promote greater changes in muscle creatine content, body composition, or training adaptations in comparison to creatine monohydrate.Journal of the International Society of Sports Nutrition 9.Suppl 1 (2012): P11.